Clinical Benefit and Safety of Microneedle Patches Composed of Magnesium: A Pilot Study in Acne Patients
Table 4
Changes in pore sizes, sebum secretion, and porphyrin level of the nose and both cheeks over time.
Variable
Mean ± SD
value
Type 3 value
Pore sizes of nose
Week 0
43.95 ± 5.39
Week 4
44.79 ± 5.33
0.1492
Week 12
46.47 ± 6.44
0.0010
0.0019
Pore sizes of both cheeks
Week 0
94.79 ± 9.62
Week 4
94 ± 10.74
0.8773
Week 12
93.12 ± 9.97
0.9004
0.6686
Sebum secretion of nose
Week 0
17.26 ± 7.97
Week 4
17.47 ± 8.76
1.5935
Week 12
17.82 ± 8.46
0.9524
0.7747
Sebum secretion of both cheeks
Week 0
23 ± 15.28
Week 4
20.74 ± 13.54
0.1962
Week 12
19.47 ± 13.18
0.2421
0.1650
Porphyrin level of nose
Week 0
40.47 ± 17.35
Week 4
36.63 ± 16.33
0.3789
Week 12
34.41 ± 22.83
0.1685
0.1442
Porphyrin level of both cheeks
Week 0
43.16 ± 38.89
Week 4
35.89 ± 34.57
0.0044
Week 12
39.12 ± 35.88
1.8416
0.0020
The mean size of pores of the nose increased significantly and the mean size of pores of both cheeks showed no difference over the course of the study. Sebum secretion did not show any difference over time, but the porphyrin level of both cheeks significantly decreased. value is corrected by Bonferroni correction. Compared to week 0. Abbreviation: SD, standard deviation.
