Research Article

A Retrospective Study of Time to Relapse following Guselkumab Withdrawal in Patients with Psoriasis

Table 1

Patient characteristics.

CharacteristicTotalRelapse groupNonrelapse group value
(N = 76)(n = 46)(n = 30)

Male, n (%)53 (69.7)30 (65.2)23 (76.7)>0.05
Age (years)38.0 (28.8, 48.2)42.0 (31.2, 48.8)33.0 (26.0, 46.8)>0.05
BMI (kg/m2)24.4 ± 3.524.8 ± 3.423.8 ± 3.8>0.05
Disease duration (years)9.0 (4.8, 13.0)9.5 (5.0, 13.0)8.0 (4.2, 10.0)>0.05
Age at disease onset (years)28 (21.0, 39.2)30 (24.2, 42.8)23.5 (18.0, 36.0)>0.05
Comorbidities, n (%)
 Psoriatic arthritis6 (7.9)5 (10.9)1 (3.3)>0.05
 Obesity11 (14.5)8 (17.4)3 (10)>0.05
 Hypertension8 (10.5)5 (10.9)3 (10.0)>0.05
 Dyslipidemia19 (25.0)13 (28.3)6 (20.0)>0.05
 Diabetes6 (7.9)5 (10.9)1 (3.3)>0.05
 Hepatitis B7 (9.2)6 (13.0)1 (3.3)>0.05
 Latent tuberculosis9 (11.8)3 (6.5)6 (20.0)>0.05
 Depression3 (3.9)1 (2.2)2 (6.7)>0.05
Comorbidities, n (%)0.006
 Yes45 (59.2)33 (71.7)12 (40.0)
 No31 (40.8)13 (28.3)18 (60.0)
 Prior biologic therapy, n (%)9 (11.8)8 (17.4)1 (3.3)>0.05
Duration of guselkumab treatment, n (%)>0.05
 4 weeks (2 doses of injections)39 (51.3)22 (47.8)17 (56.7)
 12 weeks (3 doses of injections)5 (6.6)4 (8.7)1 (3.3)
 20 weeks (4 doses of injections)31 (40.8)19 (41.3)12 (40.0)
 28 weeks (5 doses of injections)000
 36 weeks (6 doses of injections)1 (1.3)1 (2.2)0
PASI score at baseline11.7 (7.5, 20.5)11.9 (7.9, 18.5)11.6 (7.2, 21.0)>0.05
PGA score at baseline3 (3, 4)3 (3, 4)3 (3, 4)>0.05
DLQI score at baseline12.0 ± 4.811.7 ± 4.812.4 ± 5.0>0.05
PASI score at relapseNA4.6 (1.6, 8.4)NA
Duration of relapse (days)203.5 (167, 338)201 (159, 314)235 (173, 377)>0.05