Upadacitinib in the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis

Table 3

Quality assessment of the included observational studies with ROBINS-I.

Study	Study type	Bias due to confounding	Bias in selection of participants into study	Bias in classification of interventions	Bias due to deviations from intended interventions	Bias due to missing data	Bias in measurement of outcomes	Bias in selection of the reported result	Overall assessment
Blauvelt et al. [9]	CT	Moderate	Low	Low	Low	Low	Moderate	Low	Moderate
Guttman-Yassky et al. [18]	CT	Moderate	Low	Low	Low	Low	Moderate	Low	Moderate
Guttman-Yassky et al. [19]	CT	Serious	Low	Low	Low	Low	Moderate	Low	Serious
Katoh et al. [20]	CT	Moderate	Low	Low	Moderate	Low	Moderate	Low	Moderate
Reich et al. [22]	CT	Moderate	Low	Low	Moderate	Low	Moderate	Low	Moderate
Chiricozzi et al. [24]	OS	Moderate	Low	Low	Moderate	Low	Moderate	Low	Moderate
Bello et al. [27]	CS	Serious	Low	Moderate	Moderate	Moderate	Moderate	Low	Serious
Hagino et al. [23]	OS	Moderate	Low	Low	Moderate	Low	Moderate	Low	Moderate
Pereyra-Rodriguez et al. [25]	OS	Moderate	Low	Moderate	Moderate	Low	Moderate	Low	Moderate
Napolitano et al. [28]	OS	Moderate	Low	Low	Moderate	Moderate	Moderate	Low	Moderate
Feraru et al. [26]	CS	Moderate	Low	Moderate	Moderate	Low	Moderate	Low	Moderate

CT, clinical trial; CS, case series; OS, observational study.