Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Table 3

Laboratory and histological examination of 46 patients included.

Parameter	Result
Laboratory test
White blood cell (31)^a
Leukocytosis	31 (67.4%)
mm^3	15495 (10800, 48700)^b
Neutrophil (22)^a
Neutrophilia	22 (47.8%)
mm^3	12850 (7880, 29140)^b
C-reactive protein (16)^a
Normal	1 (2.2%)
Elevated	15 (32.6%)
mg/L	138 (7.2, 323.4)^b
Erythrocyte sedimentation rate (6)^a
Normal	2 (4.3%)
Elevated	4 (8.7%)
Cultures (20)^a
Negative	19 (41.3%)
Positive	1 (2.2%)
Skin biopsy (31)^a
Epidermis
Subcorneal pustule	22 (47.8%)
Spongy pustules	14 (30.4%)
Acanthosis	4 (8.7%)
Necrotic keratinocytes	4 (8.7%)
Derma
Papillary edema	7 (15.2%)
Capillary thrombosis	1 (2.2%)
Inflammatory cell infiltrate	26 (56.5%)
Neutrophilic infiltrate	4 (8.7%)
Lymphohistiocytic infiltrate	2 (4.3%)
Eosinophils infiltrate	1 (2.2%)
Mixed inflammatory infiltrate	18 (39.1%)
Lymphocyte transformation tests (2)^a
Positive	2 (4.3%)
Patch tests (19)^a
Negative	1 (2.2%)
Positive	18 (39.1%)
Skin prick tests (3)^a
Positive	3 (6.5%)
IL-36RN gene (4)^a
p.Leu27Pro	1 (2.2%)
p.Ser113Leu	1 (2.2%)
c.C338T:p.S113L	1 (2.2%)
p.Arg10X and p.Arg10ArgfsX1	1 (2.2%)

^aThe number of patients out of 46 about whom information regarding this particular parameter was provided. ^bMedian (minimum-maximum).