The Right Formula for Acne: Importance of Vehicle Formulation in Tazarotene 0.045% Lotion Design, Application, Tolerability, and Efficacy

Figure 5

Irritation potential of tazarotene 0.045% lotion vs. trifarotene 0.005% cream and adapalene 0.3% gel. At the end of 12-day modified continuous irritation patch tests, tazarotene 0.045% lotion was (a) significantly less irritating than trifarotene 0.005% cream and (b) numerically less irritating than adapalene 0.3% gel. In both studies, tazarotene 0.045% lotion was assessed as mildly irritating [39]. ; vs. control. ^### trifarotene 0.005% cream vs. tazarotene 0.045% lotion. ADAP, adapalene; TAZ, tazarotene; TRIF, trifarotene.

(a)

(b)