Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
Figure 2
A hypothetical diagram on the relationships between the variants
of FTO and/or MC4R and weight changes in the context of TE
constitutional type (a). The interaction of the obesity-related variants and TE
type may be strong for weight gain especially in a heavy population (Kirin population in this
study). Strong correlation was found between the effects of FTO haplotypes and
MC4R SNPs on body mass (BMI and WHR) and clinically measured body mass
(BMI and WHR) in each SCM type (b). The action of the genes in the context
of SCM type may differently affect body mass changes in each type. The size of
inequality sign indicates the size of body mass difference between SCM types.
