Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats

Table 1

Effect of oral administration of different doses of FIIc on fasting blood glucose (mg/dl) at various time intervals

Group	Dose	Day 0	Day 6	Day 10	Day 20	Day 30
Healthy control	—	83.10 ± 4.5	79.50 ± 10.2	84.90 ± 5.0	83.70 ± 7.6	83.50 ± 8.0
Diabetic control	—	301.5 ± 17.1	306.3 ± 12.9	313.7 ± 13.9^a	322.4 ± 10.3^a	326.3 ± 9.8^a
Diabetic + Glibenclamide	600 μg	302.9 ± 16.4	259.5 ± 39.5^a	208.3 ± 21.9^a	187.1 ± 23.2^a	144.1 ± 17.9^a
Diabetic + FIIc	10 mg	302.6 ± 13.1	300.9 ± 19.6	276.0 ± 25.4^a	213.3 ± 28.3^a	187.8 ± 16.8^a
Diabetic + FIIc	15 mg	306.5 ± 14.9	269.0 ± 31.2^a	228.5 ± 26.7^a	155.1 ± 27.4^a	121.2 ± 16.8^a
Diabetic + FIIc	20 mg	301.8 ± 12.1	298.1 ± 27.3	259.8 ± 26.2^a	195.4 ± 30.2^a	132.3 ± 18.6^a

Data are expressed as mean ± SEM of five animals in each group and evaluated by repeated measure ANOVA followed by Dunnett’s test.
^a𝑃<.001 versus day 0.