Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers

Figure 4

Effects of A. moluccana DE (batch 1; 125–500 mg/kg, p.o.) in mechanical hypernociception induced by i.d. injection of ((a) and (b)) carrageenan (300 μg/paw), ((c) and (d)) CFA (20 μL/paw), or ((e) and (f)) PGE₂ (0.1 nmol/paw) in mice. Each group represents the mean of 5 to 8 animals, and the vertical lines indicate the SEM. Significantly different from the control values *𝑃<0.05 and significantly different from saline group ^#𝑃<0.001 (two-way ANOVA followed by Bonfferroni’s post hoc test and one-way ANOVA followed by Dunnett’s post hoc test).

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(b)

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