Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers

Figure 5

((a) and (b)) Effects of the isolated compounds 2′′-O-rhamnosylswertisin and swertisin, administered orally (30 or 10 mg/kg, 1 h before) in mechanical hypernociception induced by i.d. injection of ((a) and (b)) carrageenan (300 μg/paw), ((c) and (d)) CFA (20 μL/paw) or ((e) and (f)) PGE₂ (0.1 nmol/paw) in mice. Each group represents the mean of 5 to 8 animals, and the vertical lines indicate the SEM. Significantly different from the control values *𝑃<0.05 and **𝑃<0.01 and significantly different from the saline group ^#𝑃<0.001 (two-way ANOVA followed by Bonfferroni’s post hoc test and one-way ANOVA followed by Dunnett’s post hoc test).

(a)

(b)

(c)

(d)

(e)

(f)