Antioxidant and Protective Effect of Ethyl Acetate Extract of Podophyllum hexandrum Rhizome on Carbon Tetrachloride Induced Rat Liver Injury

Table 1

Effect of P. hexandrum ethyl acetate extract on biochemical parameters in CCl₄ induced hepatotoxicity in albino rats.

Treatment and groups	Dose (mg/kg)	AST (U/L)	ALT (U/L)	LDH (U/L)
1. Control group (olive oil only)	5 mL/Kg	37.98±3.36	28.06±2.05	89.68±3.54
2. CCl4-treated group	1 mL/Kg	118.39±2.83	94.76±2.78	218.62±8.20
3. CCl4-treated + V.E	50 mg/Kg	67.55±2.18^$#	66.58±2.54^$#	170.88±5.18^$#
4. CCl4-treated + P.H extract	20 mg/Kg	100.41±5.40^$#@	79.33±5.76^$#@	193.23±5.02^$#@
5. CCl4-treated + P. H extract	30 mg/kg	65.37±2.0^$#NS	67.22±1.91^$#NS	178.10±4.61^$#b
6. CCl4-treated + P. H extract	50 mg/kg	54.16±2.96^$#@	60.03±2.73^$#@	168.50±7.20^$#b

Each value represents the mean ± S.D. of 6 animals. ^$; 𝑃<.001, as compared with normal control group, ^#; 𝑃<.001 as compared with CCl₄ group, ^@; 𝑃<.001 as compared with V.E, NS; nonsignificant as compared with V.E, b; does not test as compared with V.E. The data were presented as means ± S.D. of six parallel measures and evaluated by one way ANOVA followed by the Bonferroni 𝑡-test to detect inter group differences. Differences were considered to be statistically significant if 𝑃<.05.