Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

Figure 2

Measurement of renal cortical hypoxia-related factors in remnant kidney treated with hachimijiogan. The volume of HIF-1α protein of the four 5/6Nx groups increased significantly compared to that of the sham group, and that of the high-dose hachimijiogan group increased significantly compared to that of the control group (a). The mRNA levels of VEGF and Glut-1 of the high-dose hachimijiogan group increased significantly compared to those of the sham and control groups (b, c). (a) HIF-1α protein, (b) VEGF mRNA, (c) Glut-1 mRNA, LD-HJG: low-dose hachimijiogan, HD-HJG: high-dose hachimijiogan. Data represent mean ± S.D. (𝑛=8−10). ^∗𝑃<.05, ^∗∗𝑃<.01 versus sham group, ^#𝑃<.05, ^##𝑃<.01 versus control group.

(a)

(b)

(c)