Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis
Table 4
Effects of B. dracunculifolia extract (5 and 50 mg kg−1) and sulfasalazine (25 mg kg−1) on damage score, changes in colonic weight/length, diarrhea and adherence incidence in TNBS chronic colitis with relapse
Group
Damage scorea (0–10)
Colonic weight/lenghtb (mg cm−1)
Diarrhoea (%)
Adherence (%)
1 week
Non-colitic
0***
100.57 ± 8.03**
0*
TNBS-control
8.0 (7–9)
276.10 ± 31.17
83.3
B. dracunculifolia 5 mg kg−1
2.0 (0–4)*
140.53 ± 8.61**
0*
B. dracunculifolia 50 mg kg−1
1.0 (0–5)*
171.00 ± 22.91**
33.3
Sulfasalazine 25 mg kg−1
3.5 (2–7)
143.25 ± 20.56**
0
2 week
Non-colitic
0***
87.16 ± 4.32**
0
TNBS-control
2.5 (2–3)
185.40 ± 22.21
16.7
B. dracunculifolia 5 mg kg−1
3.0 (0–4)
117.50 ± 6.45**
0
B. dracunculifolia 50 mg kg−1
4.0 (2–5)
141.90 ± 12.02
33.3
Sulfasalazine 25 mg kg−1
4.0 (1–6)
137.95 ± 10.73
0
aScore data are expressed as median (range).
bColonic weight data are expressed as mean ± SEM.
*
P < .05, **P < .01, ***P < .001 versus TNBS control group.
