KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats

<table>Apoptosis of LECs. (a) The lens sections from a normal Zucker lean rat (ZL), vehicle-treated ZDF rat (ZDF), and ZDF rat treated with KIOM-79 (KIOM-79) were stained with a TUNEL kit. Apoptotic LECs (arrow) were observed in vehicle-treated ZDF rats. (b)  Immunofluorescence staining of cleaved caspase-3. Immunofluorescence signals for cleaved caspase-3 (red) were mainly detected in the lens epithelium of ZDF rats. X400 magnification. (c and d) Quantitative analysis of TUNEL-positive and cleaved caspase-3-positive cells in LECs. All data are expressed as means ± SE, <svg height="11.125" id="M46" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 47.575001 11.125" width="47.575001" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normal ZL rats, <sup>#</sup><svg height="11.375" id="M48" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus vehicle-treated ZDF rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats 