The Ayurvedic Medicine Salacia oblonga Attenuates Diabetic Renal Fibrosis in Rats: Suppression of Angiotensin II/AT1 Signaling
Figure 4
Angiotensin II-induced cell proliferation in rat-derived mesangial cells. SO (SO10: 10; SO20: 20 and SO40: 40 μg/ml), MA (25 μM) or telmisartan (Tel, 10 μM) was added 1 h before mesangial cells were treated with angiotensin II (10−6 M). Cell viability was determined by MTT assay ((a), n = 6, each group) and DNA synthesis was assessed by 3H-thymidine incorporation ((b), n = 6, each group), as described in “Methods” section. All values are means ± SEM. *.
