Experimental Adjustment on Drug Interactions through Intestinal CYP3A Activity in Rat: Impacts of Kampo Medicines Repeat Administered
Figure 2
(a) Effects of
oral pre-treatment with Saireito and Hochuekkito on the plasma
concentration of nifedipine after intravenous administration to rats.
(b) Effects of oral pre-treatment with Saireito and Hochuekkito
on the plasma concentration of nifedipine after intrajejunum administration to rats.
Symbols: control treated with the only solvent (open circle); pre-treatment with Saireito
(filled triangle) and Hochuekkito (filled circle) for 1 week, respectively. Each point and
vertical bars represent the mean ± SD (n = 4).
