Experimental Adjustment on Drug Interactions through Intestinal CYP3A Activity in Rat: Impacts of Kampo Medicines Repeat Administered

<table>(a) 
                Nifedipine oxidation rates and Lineweaver-Burk plots 
                in rat intestinal microsomes. (b) Nifedipine 
                oxidation rates and Lineweaver–Burk plots in rat hepatic microsomes. 
                Symbols: control treated with the solvent (open circle); pre-treatment 
                with Saireito (filled triangle) and Hochuekkito (filled circle) for 1 week, 
                respectively. Each point and vertical bars represent the mean ± SD (<i>n</i> = 4–6).</table>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Experimental Adjustment on Drug Interactions through Intestinal CYP3A Activity in Rat: Impacts of Kampo Medicines Repeat Administered 