Experimental Adjustment on Drug Interactions through Intestinal CYP3A Activity in Rat: Impacts of Kampo Medicines Repeat Administered

Table 3

Effects of oral pre-treatment with Hochuekkito or Saireito on kinetic parameters of nifedipine oxidation by rat intestinal or hepatic microsomes.

	𝐾m (𝜇mol L^−1)	𝑉max (nmol min^−1 mg^−1 protein)
Intestine
Control	66.3 ± 6.8	0.255 ± 0.020
Hochuekkito	61.0 ± 5.3	0.341 ± 0.048*
Saireito	68.7 ± 8.0	0.432 ± 0.029*
Liver
Control	66.4 ± 7.5	4.50 ± 0.81
Hochuekkito	58.4 ± 2.2	5.12 ± 0.88
Saireito	60.5 ± 8.4	5.05 ± 0.48

Each value represents the mean ± SD of 4 or 5 experiments. The kinetic parameters were calculated from the Linewaver-Burk plots in Figure 3 or Figure 4.
^∗𝑃<.05 compared with control.