Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model

Table 3

Glucose-induced insulin secretion.

	4.5 mM Glucose	16.7 mM Glucose
	pmol l^-1 per 100 islets	pmol l^-1 per 100 islets
Control	50.0 ± 1.66	87.5 ± 3.31
10 μg mL^-1 OI extract	47.7 ± 1.94	101.3 ± 1.31**
50 μg mL^-1 OI extract	61.3 ± 2.15*	112.4 ± 1.80**
100 μg mL^-1 OI extract	68.4 ± 1.52**	125.6 ± 1.30**
250 μg mL^-1 OI extract	67.0 ± 2.10*	142.9 ± 0.83**

Effect of OI extract on basal and stimulated levels of glucose induced insulin secretion. Mean ± SEM of six animals.
** P < .01, *P < .05; where * = control versus diabetic, control versus OI extract-treated. Mean ± SEM of five independent experiments. *P < .01 when compared to respective controls and **P < .01 when compared to respective controls.