A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging
Figure 2
ACAE treatment for 48 h promoted cell cycle arrest in H441GL cells. Representative cell cycle profiles of ACAE treated H441GL (a) and CGL1 (b) cells, respectively, demonstrating arrest in G0/G1 phase. X-axis (FL2-A) represents cells stained positive for PI while the Y-axis for cell counts. The percentage of cells in each phase is as indicated. (c) Cell cycle regulator molecules at transcriptional ((c), left) and translational ((c), middle) levels were examined. No significant differences were observed at the transcriptional level. However, cyclin A protein expression level decreased while cyclin E increased at 150 μg mL-1 of ACAE. Quantitative data representation of western blotting experiments in ((c), right). Each experiment was performed in triplicates (*P < .05, **P < .01).
