Original Article

KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects

Figure 4

The effect of KIOM-4 on STZ-induced mitochondrial lipid, protein and DNA damage. (a) Lipid peroxidation was detected by measuring the amount of 8-isoprostane. (b) Protein oxidation was assayed by measuring carbonyl formation. (c) DNA damage was detected measuring the amount of 8-OHdG. Asterisk represent significantly different from control cells (P < .05) and double asterisk represent significantly different from STZ-treated cells (P < .05).
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(a)
978682.fig.004b
(b)
978682.fig.004c
(c)