Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells

Table 1

Antiproliferative activity of L. pumila various extracts in human melanoma HM3KO and nonmalignant MDBK and Vero cell lines.

L. pumila extracts	IC50 values (μg/mL)
	HM3KO	MDBK	Vero
LpAE	66.41±0.78	89.30±1.95	107.62±0.98
LpEE	16.18±0.94	129.22±1.37	76.74±0.86
LpHE	35.67±0.66	57.90±1.09	36.78±1.63
Dacarbazine	5.32±0.71	39.52±0.76	54.11±0.56

All values were expressed as the means ±SD from three independent experiments: L. pumila aqueous extract-LpAE, ethanol extract-LpEE, and hexane extract-LpHE.