Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin

Figure 1

(a) Effects of 25 μM pure lovastatin, extracts of RYR products containing 25 μM lovastatin, or 25 μM PSC833 on ³H-digoxin uptake by MDCK-MDR1 cells (𝑛=3−6). (b) ³H-digoxin uptake by MDCK-MDR1 cells in the presence of 0.2–25 μM lovastatin or RYR product extracts at the same concentrations of lovastatin (𝑛=3). (c) Apical-to-basolateral flux and cellular accumulation of lovastatin after incubation of Caco-2 cells with 25 μM lovastatin or the equivalent concentration of RYR product extract (𝑛=3). ^∗𝑃<0.05 versus the lovastatin group; ^∗∗𝑃<0.01 versus the lovastatin group.

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