Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats
Figure 1
(a) Representative photomicrographs (original magnification, 200x) of PAS-stained kidney sections from STZ-diabetic rats receiving 12 weeks of DSS (2.8 g/kg/day) treatment. The vehicle (distilled water) used to disperse DSS was given at the same volume. (b) Expansion of the glomerular matrix was scored using 4 levels, and an average value was obtained from analyses of more than 30 glomeruli per rat. Values (mean ± SD) were obtained for each group of 4 animals. b compared to the values of vehicle-treated nondiabetic rats. c and d compared to the values of vehicle-treated STZ-diabetic rats, respectively.