The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model
Figure 2
The effects of intrathecal triptolide on SNL-induced mechanical allodynia. SNL injury resulted in prominent mechanical allodynia. However, the intrathecal injection of triptolide did not affect the pain threshold of the Sham-operated group. The intrathecal administration of triptolide (10 or 30 μg/kg, once per day from POD 3 to 6) significantly blocked SNL-induced mechanical allodynia in a dose-dependent manner; in contrast, 3 μg/kg/d of intrathecal triptolide did not alter the SNL-induced mechanical allodynia (a). SNL: spinal nerve ligation; POD: postoperative day. *P , compared to the SNL-Veh group. #P , compared to the SNL-T10 10 μg/kg group. The dose-effect and log- (dose-) effect curves for analgesic effects of triptolide are shown in (b) and (c). Each group consisted of 16 rats.
