The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model

Figure 7

The regulation of the expression of related proteins by triptolide after SNL (10 μg/kg) was negatively correlated with the analgesic effect of triptolide. GFAP (𝑟=−0.601; 𝑃=0.039), pJAK2 (𝑟=−0.697; 𝑃=0.012), pSTAT3 (𝑟=−0.625; 𝑃=0.030), and pNR2B (𝑟=−0.651; 𝑃=0.022) were associated with the analgesic effect of triptolide (a–d). SNL, spinal nerve ligation. Each group consisted of twelve rats. r, Pearson correlation coefficient; P, statistical significance of r. Each group consisted of 12 rats.

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