JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

<table>Effect of JCM-16021 on mucosal SERT expression in PI-IBS rats. (a) shows the immunofluorescence micrographs of (A1) negative control (primary antibody omitted) and the positive SERT expressions (arrowhead) in the mucosa of (A2) normal rats, (A3) PI-IBS rats, and (A4) high dose JCM-16021 treated rats (Scale bar, 200 <i>μ</i>m). Statistical analysis of intensity of SERT immunoreactivity is shown in (b). Data are shown as mean ± S.E.M., <svg height="10.925" id="M28" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normal rats (<i>t</i>-test).</table>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 

Figure 4 | JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 