Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice

Figure 9

Effects of shikonin on cyclooxygenase-2 expression and on nuclear translocation of p65 and phosphorylated signal transducer and activator of transcription 3. The left panels show an example of western blot following probing with the corresponding antibody. The histograms at the right represent the data derived from the western blots following densitometry analysis. Levels were normalized against β-actin or PARP-1 antibody. ^∗∗𝑃<0.01 significantly different from the colitic group; ^#𝑃<0.05, ^##𝑃<0.01 significantly different from the noncolitic group, determined by means of a one-way analysis of variance followed by Dunnett’s t-test (𝑛= 6–10).

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