Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation

Figure 2

Effect of Rg1 on the VSMC cell cycle in the presence of PDGF-BB (𝑥±𝑠, 𝑛=4∼6,%). A: representative results of flow cytometry measurements to determine the cell-cycle stages of VSMCs; B:percentage of cells in each phase of the cell cycle. Normal: vehicle; N+Rg1: Rg1 180 mg·L⁻¹; model : PDGF-BB 25 μg·L⁻¹; Rg1-L : Rg1 20 mg·L⁻¹ + PDGF-BB 25 μg·L⁻¹; Rg1-M : Rg1 60 mg·L⁻¹ +PDGF-BB 25 μg·L⁻¹; Rg1-H : Rg1 180 mg·L⁻¹ +PDGF-BB 25 μg·L⁻¹.Data were mean ± S.E.M. ^##Significant difference from normal control at 𝑃<0.01; ** significant difference from model control at 𝑃<0.01.

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