Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation

Figure 3

Effects of Rg1 on the changes of expressions of c-fos and eNOS mRNA induced by PDGF-BB in VSMC (𝑥±𝑠,𝑛=3); real-time RT-PCR analysis of c-fos, and eNOS mRNA were performed after 24 h of PDGF-BB and Rg1 actions in VSMCs. Normal : vehicle; model : PDGF-BB 25 μg·L⁻¹; Rg1-L : Rg1 20 mg·L⁻¹ + PDGF-BB 25 μg·L⁻¹; Rg1-M : Rg1 60 mg·L⁻¹ +PDGF-BB 25 μg·L⁻¹; Rg1-H : Rg1 180 mg·L⁻¹ +PDGF-BB 25 μg·L⁻¹. Data were mean ± S.E.M. ^##Significant difference from normal control at 𝑃<0.01; ** significant difference from model control at 𝑃<0.01.