Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway
Figure 3
Inhibition of PS-A on tumor growth and metastasis in vivo. (a) 2 × 106 of 786O cells were inoculated s.c. into the flank of NOD-SCID mice (). Mice were oral-administrated with water or PS-A (0.29 g/kg) for five days per week. After 45 days, mice were sacrificed and tumors were excised. The weights of tumors are represented as the means ± SD (). * compared with control. (b) 2 × 106 of 786O cells were inoculated i.v. into the tail vein of NOD-SCID mice (). Mice were oral-administrated with water or PS (0.29 g/kg) for five days per week. After 48 days, mice were sacrificed, and number of metastatic nodules of lung was counted. The number of nodules is represented as the means ± SD (). * compared with control. (c) Body weight of mice oral-administrated with water or PS-A (0.29 g/kg) for five days per week. Data are represented as the means ± SD ().
