Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity
Figure 5
Binding of syringic acid to AR. (a) Residues surrounding the syringic acid and AR. (b) Three-dimensional (3-D) graphic syringic acid docking to AR. Syringic acid interacts with AR at the 7 amino acid residues Trp111, His110, Tyr48, Trp20, Trp79, Leu300, and Phe122. (a) Trp111 and His110 have the same hydroxyl ion (–OH) at position 1, constituting an intermolecular hydrogen bond. The 3-D graphic identified intermolecular hydrogen bonds between Tyr48 and O groups at position 2.
