Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

Figure 7

Effect of GAE on different angiogenic parameters in indomethacin-induced ulcerated mice. (a) von Willebrand Factor VIII; (b) mucosal VEGF level; (c) mucosal HGF level. Ulceration in the mice was induced by indomethacin (18 mg /kg, single dose, p. o.). Treatment was carried out for 3 days with GAE (5 mg/kg, single dose daily × 3 days, p. o.) or omeprazole (3 mg/kg, p. o.) after ulcer induction. The mucosal von Willebrand Factor VIII (expressed as number of microvessels/mm²) and growth factors (expressed as ng/ml tissue extract) were measured by immunohistochemistry and colorimetry, respectively. *𝑃<0.05, **𝑃<0.01, compared to normal mice; ^#𝑃<0.01, ***𝑃<0.001, compared to untreated mice.

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