Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells
Figure 6
Flavonoids alter the expression of apoptosis-related proteins caspase-8, -9, -3, and -6, and cleavage of PARP. The expression of proteins was assessed by immunoblotting. (a) Representative blots are shown. Densitometric analysis of the effect of flavonoids on the expression of procaspase-8 (b), -9 (c), -3 (d), and -6 (e), and cleaved PARP (f). (g) Caspase-3 activity was determined using a colorimetric caspase-3 activation kit assay kit following the manufacturer’s protocol. Each value represents the mean of three experiments; bars, ±SD. (*, ** versus control group.)
