Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways

Figure 3

Administration of Platycodi Radix ameliorates weight gain and insulin resistance. Mice were fed 10% kCal fat diet (D12450B), 60% kCal high fat (D12492) diet (Research Diets, New Brunswick, NJ), 0.1% and 1% WBF Platycodon radix in 60% kCal for 10 weeks. Body weight and food intakes were measured every week. (a) Body weight changes for 9 weeks, fed status. (b) Fasting blood glucose. (c) Fasting serum insulin. (d) HOMA-IR. Data are mean ± SEM. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001 on ND versus HFD. ^#𝑃<0.05; ^##𝑃<0.01; ^###𝑃<0.001 on HFD versus WBF PR-treated group.

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