Influence of Fructooligosaccharide on Pharmacokinetics of Isoflavones in Postmenopausal Women

Table 2

Pharmacokinetic parameters of daidzein and genistein obtained from 12 subjects receiving a single oral administration of soy beverage (single ISO phase) and continuous oral administrations of FOS following by a single oral administration of soy beverage (continuous FOS/single ISO phase).

Pharmacokinetic parameters	Daidzein		Genistein
	Single ISO	Continuous FOS/single ISO	Single ISO	Continuous FOS/single ISO
Cmax (ng/mL)	363.33±116.67	412.90±100.61	347.01±143.42	489.65±187.15^∗
AUC0–32 (ng·h·mL)	2753.71±1227.64	3177.32±1474.55^∗	4096.66±2050.96	5354.39±2650.16^∗
AUC0–∞ (ng·h·mL)	3399.35±1261.82	3741.85±1421.28	5075.62±2787.77	6321.17±3047.63^∗
𝑇max (h)	6.67±1.78	6.67±1.78	6.00+1.91	6.67±1.56
𝑡1/2 (h)	4.65±2.46	5.27±2.50	9.61±4.45	10.01±4.17

Data represents mean ± SD. ^∗𝑃<0.05 versus single ISO phase.