The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
Figure 5
The effects of retigabine, flupirtine and lamotrigine on repetitive muscle contractions evoked by indirect (nerve)- and direct (muscle)- stimulation at a frequency of 20 Hz in the presence of 9-AC (0.1 mM). (a)–(c) and (d)–(f) are the muscle contractions evoked by the indirect and direct stimulation at a frequency of 20 Hz with 3 sec duration, respectively. (a, d): retigabine (0.03 mM); (b, e): flupirtine (0.03 mM); (c, f): lamotrigine (0.03 mM). TCM index: tetanic contraction maintenance index. * as compared with 9-AC alone; N.S: no significance.
