Hesperidin-3′-O-Methylether Is More Potent than Hesperidin in Phosphodiesterase Inhibition and Suppression of Ovalbumin-Induced Airway Hyperresponsiveness

Figure 6

Effects of hesperidin (a–e) and hesperidin-3′-O-methylether (f–j) on total IgE (a, c, f, and h) and ovalbumin-specific IgE (b, d, g, and i) levels in bronchial alveolar lavage fluid (a, b, f, and g) and serum (c, d, h, i), and total IgG_2a (e, j) levels in serum of sensitized mice which had received aerosolized methacholine (6.25~50 mg/mL) 2 days after primary allergen challenge. ^#𝑃<0.05, ^##𝑃<0.01, and ^###𝑃<0.001, compared to the nonchallenged group. *𝑃<0.05 and **𝑃<0.01, compared to the control (vehicle) group. Each value represents the mean ± SEM. The number of mice in each group was 10.