Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae

Table 2

The top 10 drug molecules affected pathways with Fuzheng Huayu Capsule or placebo.

(a) Patient A

cMap ID	Drug molecule	Dose	Pathway counts
169	Tacrolimus	1 uM	22+
383	Cobalt chloride	100 uM	21+
144	Chlorpropamide	100 uM	20+ 1−
641	Benserazide	10 uM	20+
576	Novobiocin	100 uM	20−
487	Pirinixic acid	100 uM	20−
421	Trifluoperazine	10 uM	20+
314	Exisulind	50 uM	20+
284	Tacrolimus	1 uM	20+
268	Genistein	1 uM	20+

(b) Patient B

cMap ID	Drug molecule	Dose	Pathway counts
487	Pirinixic acid	100 uM	53+
161	Verapamil	10 uM	52+
2	Metformin	10 uM	52+
419	Chlorpromazine	10 uM	49+
49+	Sirolimus	100 nM
49+	Dexverapamil	10 uM
141	Chlorpropamide	100 uM	49+
122	Alpha-estradiol	10 nM	49+
457	Tetraethylenepentamine	100 uM	47−
124	Mesalazine	100 uM	46+

(c) Patient C

cMap ID	Drug molecule	Dose	Pathway counts
608	NU-1025	100 uM	4−
418	Haloperidol	10 uM	4+
282	Fludrocortisone	1 uM	4+
1072	Trichostatin A	1 uM	3+
984	Acetylsalicylic acid	100 uM	3+
1009	Clozapine	10 uM	3+
1017	Fluphenazine	10 uM	3+
1024	Haloperidol	10 uM	3+
995	Prochlorperazine	10 uM	3−
887	Celastrol	3 uM	3+