Research Article

Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

Figure 4

The increase in (a) and the decrease in CL (b) of MDZ (10 mg/kg, i.v.) after treatment with baicalin at a single dose of 0.225 g/kg ( ) or 0.45 g/kg ( ) or at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days ( ).
179643.fig.004a
(a)
179643.fig.004b
(b)