Research Article

Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivo and In Vitro

Figure 8

QHD inhibits hepatic lipid accumulation by activating AMPK. QHD significantly stimulates AMPK phosphorylation, decreases nuclear SREBP-1 and ChREBP protein contents, down-regulates ACCα expression and up-regulates phosphorylation of ACCα, and then decreases hepatic de novo lipogenesis and accumulation.
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