Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats

Figure 1

Astragaloside IV(AS-IV) improved renal dysfunction in rats with ischemic AKI. Serum creatinine (a), BUN (c), and cystatin C (e) in sham, vehicle-, or AS-IV-pretreated rats at 12 h of reperfusion. Serum creatinine (b), BUN (d), and cystatin C (f) in sham, vehicle-, or AS-IV-pretreated rats at 24 h of reperfusion. Sham, sham-operated rats treated with normal saline; Veh, ischemia-reperfusion (IR) rats pretreated with carboxymethyl cellulose vehicle alone served as control; AL, IR rats pretreated with AS-IV (10 mg·kg⁻¹·d⁻¹); AH, IR rats pretreated with AS-IV (20 mg·kg⁻¹·d⁻¹). Results are expressed as mean ± SD (𝑛=8). ^∗𝑃<0.05 versus Sham group; ^#𝑃<0.05 versus Veh group.

(a)

(b)

(c)

(d)

(e)

(f)