Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats

Figure 5

AS-IV decreased the serum levels of TNF-α, MCP-1, and ICAM-1 in rats with ischemic AKI. Serum levels of TNF-α (a), MCP-1 (b), and ICAM-1 (c) in sham, vehicle-, or AS-IV-pretreated rats at 12 h of reperfusion. Serum levels of TNF-α (d), MCP-1 (e), and ICAM-1 (f) in sham, vehicle-, or AS-IV-pretreated rats at 24 h of reperfusion. Results are expressed as mean ± SD (𝑛=8). ^∗𝑃<0.05 versus Sham group; ^#𝑃<0.05 versus Veh group.

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