Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats
Figure 7
AS-IV downregulated the mRNA expression of TNF-α, MCP-1, and ICAM-1 in rats with ischemic AKI. Representative real-time PCR of TNF-α (a), MCP-1 (b), and ICAM-1 (c) in renal tissues from sham, vehicle-, or AS-IV-pretreated rats at 12 h of reperfusion. Representative real-time PCR of TNF-α (d), MCP-1 (e), and ICAM-1 (f) in renal tissues from sham, vehicle-, or AS-IV-pretreated rats at 24 h of reperfusion. Results are expressed as mean ± SD. versus Sham group; versus Veh group.
