Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells

Figure 5

Effects of inhibitors on Timosaponin AIII suppressed HGF-induced invasive activity. The in vitro invasiveness of MDA-MB-231 cells was assessed using a modified Boyden chamber as described in Section 2. Timosaponin AIII-inhibited HGF-induced invasive activity could be completely blocked by COX2 inhibitor (NS398) and partially blocked by ERK inhibitor (PD98059).