Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells
Figure 7
Effects of Timosaponin AIII on the kinetics of ERK phosphorylation and ATF2 expression in MDA-MB-231 cells. The nuclear extraction proteins induced by HGF were analyzed by Western blot as described in Section 2. The results showed a kinetic increased expression of p-ERK (a) and ATF2 (b) with the peak at 2 h and 6 h, respectively. TAIII (10−7 M) changed the kinetics of p-ERK induced by HGF with the peak at 6 h, while suppressed HGF-induced nuclear ATF2 expression.
