Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis

Table 2

Metabolic pathway enrichment analysis of the metabolites identified as potential biomarkers.

Pathway name	𝑃 value	Adj. 𝑃 value	Hits	Metabolites
Aminoacyl-tRNA biosynthesis	8.91𝐸−07	3.56𝐸−05	5	L-phenylalanine, L-valine L-tryptophan, L-tyrosine, and methionine
Phenylalanine, tyrosine, and tryptophan biosynthesis	4.93𝐸−05	9.86𝐸−04	3	L-tyrosine, L-tryptophan, and L-phenylalanine
Vascular smooth muscle contraction	0.002215	0.011075	2	cGMP, cAMP
Melanogenesis	1.14𝐸−04	0.00114	2	cAMP, L-tyrosine
Sphingolipid metabolism	0.002215	0.011075	2	Sphinganine, phytosphingosine
Phenylalanine metabolism	0.007401	0.032893	2	L-phenylalanine, L-tyrosine
ABC transporters	0.026777	0.101461	2	L-valine, L-phenylalanine
Purine metabolism	0.027902	0.101461	2	cAMP, cGMP
Gap junction	4.15𝐸−04	0.003319	2	cGMP, cAMP

𝑃 value, statistically assessed against the background set; adj. 𝑃 value, 𝑃 value corrected using the false discovery rate.