Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function

Figure 4

Curcumin inhibited neuroinflammatory response in cerebral ischemia of rat through activating PPARγ. Rats were injected (i.p.) with curcumin and GW9662 for continuous 3 days. One hour after the last injections, the rats were subjected to MCAO for 2 h and reperfused for 24 h. And the cortex was isolated for detection of inflammatory mediators. (a) ELISA assay of IL-1β. (b) ELISA assay of TNF-α. (c) ELISA assay of PGE2. (d) NO concentration. Data were expressed as mean ± SD with 6 individual rats per group. *𝑃<0.05, **𝑃<0.01 versus sham-operated rats, ^##𝑃<0.01 versus MCAO rats, ^Δ𝑃<0.05, and ^ΔΔ𝑃<0.01 versus curcumin-treated rats.

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