Microarray Analysis Reveals the Molecular Basis of Antiarthritic Activity of Huo-Luo-Xiao-Ling Dan

Table 2

The gene expression profiles of Bhsp65-restimulated LNC of HLXL-treated and vehicle (Water)-treated rats.

Gene function	HLXL-treated		Water-treated
	UR-DEG	DR-DEG	UR-DEG	DR-DEG
Immune response-related	36	4	41	7
Cell proliferation and apoptosis	3	3	13	4
Binding activity	6	0	5	1
Metabolism
Lipid metabolism-related processes	6	2	6	2
Other metabolic processes	2	1	3	1
Undefined	7	6	19	6
Angiogenesis	1	1	1	1
Signal transduction and pathways	1	2	1	2
Autoantigen	0	0	1	0
Others	0	0	3	0
Transport	2	1	1	2
Sub-total	64	20	94	26
Total	84		120

UR: upregulated; DR: downregulated; DEG: differentially expressed genes. DEG in response to Bhsp65-restimulation of LNC were compared. The gene expression profile of LNC cultured with Bhsp65 was compared with that of LNC in medium (med) using the cut off 𝑃<0.05 corrected with Benjamin-Hochberg, fold change >2.0 as described in Section 2.6. The functional categories of these DEG were based on the main biological processes involving them.