Inhibition of LXR𝜶/SREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule

Figure 5

JZG reduced expression of SREBP-1c-related genes and proteins independent of LXR𝛼. (a) The effect of JZG on FFA-induced SREBP-1c and FAS mRNA expression levels in LXR𝛼 knockdown HepG2 cells. (b) The effect of JZG on FFA-induced pSREBP-1c, mSREBP-1c, and FAS protein expression levels in LXR𝛼 knockdown HepG2 cells. The data represent the mean ± SEM of three separate measurements. *𝑃<0.05 and **𝑃<0.01 versus the control group, ^#𝑃<0.05 and ^##𝑃<0.01 versus the FFA group.

(a)

(b)