The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Figure 8

Effects of SnPP on the inhibition of ALA on LPS-induced NO_x level in BALF, iNOS and nitrotyrosine expression in lung tissues. Rats were pretreated with ALA 1 h before intratracheal instillation of LPS for 6 h. In some rats, SnPP was administered 2 h and ALA 1 h before LPS instillation. The NO_x level in BALF (a), iNOS (b) and nitrotyrosine expression (c) in lungs were measured. Data were represented as means ± SEM (𝑛=5). *𝑃<0.05 versus LPS-instilled alone group; ^#𝑃<0.05 versus LPS+ALA group.

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